A 15-year-old male presents with an ill-defined, large mass deep in his right thigh. A biopsy is performed, and a representative section is shown here.
What is the diagnosis?
A. Burkitt lymphoma
B. Malignant fibrous histiocytoma
C. Leiomyosarcoma
D. Rhabdomyosarcoma
E. Ganglioneuroblastoma
(Scroll down for the answer)
The diagnosis in this case is rhabdomyosarcoma. Rhabdomyosarcoma is divided into three variants: embryonal, alveolar and pleomorphic rhabdomyosarcoma. The alveolar variant, as shown in this case, commonly arises in the deep musculature of the extremity, and represents 20% of all cases of rhabdomyosarcoma. Histologically, the tumor cells are aligned along fibrous septae that create spaces resembling the alveolar spaces in the lung. The tumor cells are small to moderate in size, with minimal cytoplasm. Prognosis is poor, particularly for tumors which have a t(2;13) translocation.
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hi kris madam just i hav queation
Is Feritine is more specific test for iron deficiency anema
or Iron and tsbi
Yes! In fact, some clinicians will start with just a ferritin level, and if that is low, then it’s iron-deficiency anemia. There are other anemias that can mimic the low serum iron and high TIBC of iron-deficiency, so those tests are less specific. ONE CAVEAT THOUGH (and it’s so important I had to use caps!): ferritin is also an acute phase reactant! So it will go up in the blood when there is inflammation (like in sepsis, for example). SO: the ferritin is ONLY useful if it is LOW. If the ferritin is NORMAL or HIGH, the patient still could be iron-deficient (if the patient also had an inflammatory condition that would make the ferritin go up).
Bottom line: Low ferritin = iron-deficiency anemia. Normal or high ferritin = DOESN’T RULE OUT iron-deficiency anemia.
Why basal cell carcinoma doesn’t metastasize?
I don’t know! Basal cell carcinoma is a real carcinoma – but unlike most other carcinomas, it hardly ever metastasizes. I don’t know the reason for that…someone has probably worked on that question though.
Dear Sandeep first thing basal cell carcinomas some times do metastases but it’s rare.The reason could be that the metastatic genes might not triggered like how it get triggered in squmous cell carcinoma.The reason is not known clearly. But rarely basal cell carcinoma can also be metastatic.