A 44 year-old male with progressive weakness

A 44 year-old male presents with a several-week history of progressive weakness and visual changes. His family has noted a personality change over the past few months. An MRI shows multifocal, non-enhancing lesions involving the cortical white matter. A biopsy of one of the lesions is shown here.
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A 57 year-old male with fatigue and LUQ heaviness

A 57 year-old male presents with fatigue and left upper quadrant heaviness. His white blood cell count is 110 x 109/L, and his hemoglobin is 8 g/dL. A bone marrow biopsy is performed, and in addition to a marked increase in neutrophils and precursors, a rare cell such as the one depicted here is present.

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25 year-old male with rapidly-growing forearm mass

A 25 year-old male presents with a mass on the volar aspect of his forearm. He first noticed the lesion 2 weeks ago, when he developed pain in his arm, and since then it has grown rapidly to reach its current size of approximately 5 cm. (more…)